Addressing workers at a factory in Stoke, where 69.4% of voters backed Leave, the prime minister will also say that if the referendum result is not honoured, people’s faith in politics will suffer “catastrophic harm”.

When the people are asked to decide something, their response carries a “profound significance”, she will add.

Speaking the day before MPs vote on her withdrawal agreement, the PM will claim that some in Westminster will use “every device available to them” to “delay or even stop Brexit”.

It was reported on Sunday that there is a backbench plot to wrest control of the legislative agenda away from Mrs May if her deal fails.

Were such a plan to succeed, the government would lose control of parliamentary business, threatening its ability to govern, putting Brexit legislation at risk.

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